Phage Therapy Faces Evolutionary Challenges
نویسندگان
چکیده
منابع مشابه
Challenges in predicting the evolutionary maintenance of a phage transgene
BACKGROUND In prior work, a phage engineered with a biofilm-degrading enzyme (dispersin B) cleared artificial, short-term biofilms more fully than the phage lacking the enzyme. An unresolved question is whether the transgene will be lost or maintained during phage growth - its loss would limit the utility of the engineering. Broadly supported evolutionary theory suggests that transgenes will be...
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متن کاملPhage therapy
Bacteriophage therapy, the use of viruses that infect bacteria as antimicrobials, has been championed as a promising alternative to conventional antibiotics. Although in the laboratory bacterial resistance against phages arises rapidly, resistance so far has been an only minor problem for the effectiveness of phage therapy. Resistance to antibiotics, however, has become a major issue after deca...
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I n a note published in The Lancet in December 1915, Frederic Twort described the discovery of an infectious, filterable agent that causes the glassy transformation and eventual killing of bacteria, now identified as Staphylococcus hyicus [1]. Two years later, Félix d’Herelle independently described an invisible microbe antagonistic to dysentery bacilli in a note to the Comptes Rendus de l’Acad...
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Engineered genetic systems are commonly unstable; if propagated, they evolve to reverse or modify engineered elements because the elements impair fitness. A goal of synthetic biology is thus to anticipate and avoid detrimental engineering, but little is yet known about which types of elements cause problems in different contexts. In prior work, 30% of the genome of bacteriophage T7 was "refacto...
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ژورنال
عنوان ژورنال: Viruses
سال: 2018
ISSN: 1999-4915
DOI: 10.3390/v10060323